Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data

V Rethnam; P Langhorne; L Churilov; KS Hayward; F Herisson; SR Poletto; Y Tong; J Bernhardt

Journal article

Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data

V Rethnam, P Langhorne, L Churilov, KS Hayward, F Herisson, SR Poletto, Y Tong, J Bernhardt

Disability and Rehabilitation | TAYLOR & FRANCIS LTD | Published : 2020

DOI: 10.1080/09638288.2020.1789229

Abstract

Purpose: To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual participant data (IPD). Materials and methods: IPD were sought from randomised controlled trials comparing out-of-bed mobilisation starting within 48 h from stroke onset to usual care for acute stroke patients. Six trials were sourced from a recent Cochrane review. Favourable outcome (modified Rankin Scale 0–2) and death at 3 months post-stroke were compared between both groups using mixed-effect logistic regression modelling. Adjusted odds ratios (aORs) with respective 95% confidence intervals (95%CI) were reported. Results: Out of 2630 participants, 1437 (54.6%) we..

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University of Melbourne Researchers

Leonid Churilov Author

Kate Hayward Author

Julie Bernhardt Author

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Grants

Awarded by National Institute for Health and Care Research

Funding Acknowledgements

V.R. was supported by a Postgraduate Scholarship from NHMRC Centre of Research Excellence in Stroke Recovery and Brain Rehabilitation [1077898]. P.L. was supported by the NIHR Cochrane Incentive Grant. NHMRC of Australia Fellowships supported KSH [1088449] and JB [1154904].